Standardisation and harmonisation of thyroid-stimulating hormone measurements: historical, current, and future perspectives
Cowper B, Lyle AN, Vesper HW, Van Uytfanghe K, Burns C. Clin Chem Lab Med. 2024 - doi: 10.1515/cclm-2023-1332. Epub ahead of print
WHO 4th International Standards for TSH (human, pituitary)
WHO REFERENCE NUMBER: WHO/BS/2023.2454
Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status
Van Uytfanghe K, Ehrenkranz J, Halsall D, Hoff K, Loh TP, Spencer CA, Köhrle J. Thyroid. 2023;33:1013-1028.
Practical considerations for accurate determination of free thyroxine by equilibrium dialysis
Ribera A, Zhang L, Ribeiro C, Vazquez N, Thonkulpitak J, Botelho JC, Danilenko U, van Uytfanghe K, Vesper HW. J Mass Spectrom Adv Clin Lab 2023;29:9-15.
Description and validation of an equilibrium dialysis ID-LC-MS/MS candidate reference measurement procedure for free thyroxine in human serum
Jansen HI, van der Steen R, Brandt A, Olthaar AJ, Vesper HW, Shimizu E, Heijboer AC, Van Uytfanghe K, van Herwaarden AE. Clin Chem Lab Med 2023;61:1605-1611.
Development of an equilibrium dialysis ID-UPLC-MS/MS candidate reference measurement procedure for free thyroxine in human serum
Ribera A, Zhang L, Dabbs-Brown A, Sugahara O, Poynter K, van Uytfanghe K, Shimizu E, van Herwaarden AE, Botelho JC, Danilenko U, Vesper HW. Clin Biochem 2023;116:42-51.
Clinical Interpretation of Thyroid Tests: Considerations for Reference Intervals
Loh TP, Ehrenkranz J, Halsall D, Spencer CA, Van Uytfanghe K, Köhrle J. Thyroid 2023;33:404-406.
Implementing reference systems for thyroid function tests - A collaborative effort
Vesper HW, Van Uytfanghe K, Hishinuma A, Raverot V, Patru MM, Danilenko U, van Herwaarden AE, Shimizu E. Clin Chim Acta 2021;519:183-186.
Summary of activities to collect information about concerns and potential risks associated with changes in reference intervals for free thyroxine and TSH and about communication and interactions among relevant stakeholders
The C-STFT under the leadership Prof. Linda Thienpont, Dr. Jim Faix, and Dr. Graham Beastall performed broad initiatives world-wide to create awareness about harmonization and standardization of TSH and fT4 assays among assay manufacturers, clinical laboratories, endocrinologists, physicians, and patients.
Seasonal changes in serum TSH concentrations observed from a big dataset obtained during 6 consecutive years from 2010 to 2015 at a single hospital in Japan.
Yoshihara A, Noh J, Watanabe N, Iwaku K, Kunii Y, Ohye H, Suzuki M, Matsumoto M, Suzuki N, Sugino K, Thienpont L, Hishinuma A, Ito K. Thyroid 2018;28:429-436.
Standardization of free thyroxine measurements paves the way for the adoption of a more uniform reference interval
De Grande LAC, Van Uytfanghe K, Reynders D, Das B, Faix JD, MacKenzie F, Decallonne B, Hishinuma A, Lapauw B, Taelman P, Van Crombrugge P, Van den Bruel A, Velkeniers B, Williams P, Thienpont LM on behalf for the IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chem 2017;63:1642-52.
Harmonization of serum thyroid-stimulating hormone measurements paves the way for the adoption of a more uniform reference interval.
Thienpont LM, Van Uytfanghe K, De Grande LAC, Reynders D, Das B, Faix JD, MacKenzie F, Decallonne B, Hishinuma A, Lapauw B, Taelman P, Van Crombrugge P, Van den Bruel A, Velkeniers B, Williams P on behalf for the IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chem 2017;63:1248-60.
Using "big data" to describe the effect of seasonal variation in thyroid-stimulating hormone.
De Grande LA, Goossens K, Van Uytfanghe K, Halsall I, Yoshimura Noh J, Hens K, Thienpont LM. Clin Chem Lab Med 2017;55:e34-e36.
Monitoring the stability of the standardization status of FT4 and TSH assays by use of daily outpatient medians and flagging frequencies.
De Grande LA, Goossens K, Van Uytfanghe K, Das B, MacKenzie F, Patru MM, Thienpont LM; IFCC Committee for Standardization of Thyroid Function Tests (C-STFT). Clin Chim Acta. 2017;467:4-18.
Standardization of Thyroid Tests. The future standardization of FT4 and harmonization of TSH measurements in serum. A request for input on benefits and risks from Thyroid Foundations.
Thienpont LM, Faix JD, Beastall G. ThyroWorld Volume 18 Summer 2015; 13-4.
Standardization of Free Thyroxine and Harmonization of Thyrotropin Measurements: A Request for Input from Endocrinologists and Other Physicians.
Thienpont LM, Faix JD, Beastall G. Thyroid 2015;25:1379-80. Clin Endocrinol (Oxf) 2016;84:305-6. Endocr J 2015;62:855-6. Exp Clin Endocrinol Diabetes 2016;124:61-2. Endocrine 2015;50:826-7. Eur Thyroid J 2015;4:217-2. Endocr Pract 2016;22:374.
A Fresh Look at the Relationship between TSH and Free Thyroxine in Cross-Sectional Data.
De Grande LAC, Van Uytfanghe K, Thienpont LM. Eur Thyroid J 2015;4:69-70.
A Progress report of the IFCC Committee for Standardization of Thyroid Function Tests.
Thienpont LM, Van Uytfanghe K, Van Houcke S, Das B, Faix JD, MacKenzie F, Quinn FA, Rottmann M, Van den Bruel A. Eur Thyroid J 2014;3:109-116.
Time to standardize thyroid function testing.
Thienpont LM, van Uytfanghe K. The Pathologist 2014; Nov: 29-27 (www.thepathologist.com).
A "Step-Up" approach for harmonization.
Van Uytfanghe K, De Grande LA, Thienpont LM. Clin Chim Acta 2014;432:62-67.
A statistical basis for harmonization of thyroid stimulating hormone immunoassays using a robust factor analysis model.
Stöckl D, Van Uytfanghe K, Van Aelst S, Thienpont LM. Clin Chem Lab Med 2014;52:965-72.
Thyroid-Stimulating Hormone. Why efforts to harmonize testing are critical to patient care.
Faix JD, Thienpont LM. Clin Labor News 2013;39 no. 5.
Harmonization of immunoassays to the all-procedure trimmed mean - proof of concept by use of data from the insulin standardization project.
Van Houcke SK, Van Aelst S, Van Uytfanghe K, Thienpont LM. Clin Chem Lab Med 2013;51:e103-5. doi: 10.1515/cclm-2012-0661.
Determination of free thyroid hormones.
Thienpont LM, Van Uytfanghe K, Poppe K, Velkeniers B. Best Pract Res Clin Endoc Metab 2013;27:689-700.
"Good samples make good assays" - the problem of sourcing clinical samples for a standardization project.
Van Houcke SK, Thienpont LM. Clin Chem Lab Med. 2013;51:967-72.
Roadmap for Harmonization of clinical laboratory measurement procedures.
Miller WG, G.L. Myers, M.L. Gantzer, S.E. Kahn, E.R. Schönbrunner, L.M. Thienpont, D.M. Bunk, R.H. Christenson, J.H. Eckfeldt, S.F. Lo, C.M. Nübling, C.M. Sturgeon. Clin Chem 2011;57:1108-17.
IFCC international conventional reference procedure for the measurement of free thyroxine in serum.
Van Houcke SK, Van Uytfanghe K, Shimizu E, Tani W, Umemoto M, Thienpont LM. Clin Chem Lab Med 2011;49:1275-81.
Traceability to a common standard for protein measurements by immunoassay for in-vitro diagnostic purposes.
Thienpont LM, Van Houcke SK. Clin Chim Acta. 2010;411:2058-61.
Standardization activities in the field of thyroid function tests: a status report.
Thienpont LM, Van Uytfanghe K, van Houcke S. Clin Chem Lab Med 2010;48:1577-83.
FT4 immunoassays may display a pattern during pregnancy similar to the equilibrium dialysis ID-LC/tandem MS candidate reference measurement procedure in spite of susceptibility towards binding protein alterations.
Anckaert E, Poppe K, Van Uytfanghe K, Schiettecatte J, Foulon W, Thienpont LM. Clin Chim Acta 2010;411:1348-53.
Report of the IFCC Working Group for Standardization of Thyroid Function Tests, Part 3: Total Thyroxine and Total Triiodothyronine.
Thienpont LM, Van Uytfanghe K, Beastall G, Faix JD, Ieiri T, Miller WG, Nelson JC, Ronin C, Ross HA, Thijssen JH, Toussaint B. Clin Chem 2010;56:921-9.
Report of the IFCC Working Group for Standardization of Thyroid Function Tests, Part 2: Free Thyroxine and Free Triiodothyronine.
Thienpont LM, Van Uytfanghe K, Beastall G, Faix JD, Ieiri T, Miller WG, Nelson JC, Ronin C, Ross HA, Thijssen JH, Toussaint B. Clin Chem 2010;56:912-20.
Report of the IFCC Working Group for Standardization of Thyroid Function Tests, Part 1: Thyroid-Stimulating Hormone.
Thienpont LM, Van Uytfanghe K, Beastall G, Faix JD, Ieiri T, Miller WG, Nelson JC, Ronin C, Ross HA, Thijssen JH, Toussaint B. Clin Chem 2010;56:902-11.
A Major Step Forward in the Routine Measurement of Serum Free Thyroid Hormones.
Thienpont LM. Clin Chem 2008;54:625-6.
Proposal of a Candidate International Conventional Reference Measurement Procedure for Free Thyroxine in Serum.
Thienpont LM, Beastall G, Christofides ND, Faix JD, Ieiri T, Jarrige V, Miller WG, Miller R, Nelson JC, Ronin C, Ross HA, Rottmann M, Thijssen JH, Toussaint B. Clin Chem Lab Med 2007;45:934-6.
Measurement of Free Thyroxine in Laboratory Medicine - Proposal of Measurand Definition.
Thienpont LM, Beastall G, Christofides ND, Faix JD, Ieiri T, Miller WG, Miller R, Nelson JC, Ross HA, Ronin C, Rottmann M, Thijssen JH, Toussaint B. Clin Chem Lab Med 2007;45:563-4.
Use of Frozen Sera for FT4 Standardization: Investigation by Equilibrium Dialysis Combined with Isotope Dilution-Mass Spectrometry and Immunoassay.
Van Uytfanghe K, Stöckl D, Ross HA, Thienpont LM. Clin Chem 2006;52:1817-21.
Feasibility Study of the Use of Frozen Human Sera in Split-Sample Comparison of Immunoassays with Candidate Reference Measurement Procedures for Total Thyroxine and Total Triiodothyronine Measurements.
Thienpont LM, Van Uytfanghe K, Marriott J, Stokes P, Siekmann L, Kessler A, Bunk D, Tai S. Clin Chem 2005;51:2303-11.
Metrologic traceability of total thyroxine measurements in human serum: efforts to establish a network of Reference Measurement Laboratories.
Thienpont LM, Van Uytfanghe K, Marriot J, Stokes P, Siekmann L, Kessler A, Bunk D, Tai S. Clin Chem 2005;51:161-8.
Development of a simplified sample pretreatment procedure as part of an Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry candidate reference measurement procedure for serum total thyroxine.
Van Uytfanghe K, Stöckl D, Thienpont LM. Rapid Commun Mass Spectrom 2004;18:1539-40.
Isotope Dilution-Gas Chromatography/Mass Spectrometry and Liquid Chromatography/Electrospray Ionization-Tandem Mass Spectrometry for the determination of triiodo-L-thyronine in serum.
Thienpont LMR, Fierens C, De Leenheer AP, Przywara L. Rapid Commun Mass Spectrom 1999;13:1924-31.
Isotope Dilution-Liquid Chromatography/Electrospray Ionization-Tandem Mass Spectrometry for the determination of serum thyroxine as a potential reference method.
De Brabandere VI, Hou P, Stöckl D, Thienpont LM, De Leenheer AP. Rapid Commun Mass Spectrom 1998;12:1099-03.